Chemical found in cannabis could provide a breakthrough in preventing opioid overdose

Indiana scientists identify 15 CBD extracts that can reverse the deadly impact of fentanyl on the brain

According to recent studies, 1,500 Americans die every two weeks from an overdose caused by fentanyl, a highly potent opioid. Narcan is currently the only FDA-approved drug available to reverse overdoses. However, scientists at Indiana University may have found a critical use for a chemical found in cannabis – cannabidiol (CBD) – that could prevent overdoses.

Researchers at Indiana University have identified 15 chemicals derived from CBD, which can reverse the deadly impact of drugs such as fentanyl on the brain. In fact, these CBD extracts were found to be even more effective than Narcan at stopping fentanyl in the brain. Fentanyl-class compounds account for more than 80% of opioid overdose deaths.

Study finds CBD compounds may reduce fentanyl binding and boost naloxone’s effect

Researchers at Indiana University have developed compounds based on CBD that reduce fentanyl binding and boost the effects of naloxone. While naloxone is the ideal alternative for reversing overdoses, finding something that works synergistically with it would also be a success.

CBD can interfere with opioid binding indirectly by altering the shape of the receptor, a fact evident when used with naloxone. It can accelerate the medication’s effect by forcing receptors to release opioids. Researchers altered the structure of CBD to generate derivatives that were tested at varying concentrations against fentanyl, with and without naloxone. Several derivatives could reduce fentanyl binding even at incredibly low concentrations while outperforming naloxone’s opioid-blocking performance.

Companies are developing drugs to reverse cannabis overdose

While it seems ironic, cannabis overdose is possible and becoming more common with relaxed marijuana laws. THC overdose can cause uncomfortable symptoms such as rapid heart rate and paranoia. Children who accidentally eat cannabis edibles can become comatose and require hospitalization. As a result, companies are developing drugs to reverse THC overdose, similar to the drug naloxone used to reverse opioid overdoses.

Drinabant and ANEB001 are both CB-1 receptor antagonists being developed as treatments for THC overdose and cannabinoid hyperemesis syndrome. However, some experts are concerned about their safety since they relate to a medication called rimonabant, which has been associated with severe mental health episodes and allergic reactions. The companies developing these drugs defend their safety and effectiveness and prepare to release clinical trial data to support their claims.

Conclusion

Fentanyl is up to 100 times more potent than morphine, making it lethal even in small doses. It is responsible for the decrease in life expectancy in America. Narcan is the only drug available to reverse an overdose, making sense to look at alternatives. The development of CBD-based drugs has opened up new avenues for the treatment of opioid overdoses. CBD is emerging as a significant player in preventing opioid abuse and related overdoses.

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